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Nevertheless, A/B testing has challenges and blind spots, such as: the difficulty of identifying suitable metrics that give "works well" a measurable meaning. accounting for effects "orthogonal" to the randomization used in experimentation. accounting for effects "orthogonal" to the randomization used in experimentation.
Having calculated AUC/AUMC, we can further derive a number of useful metrics like: Total clearance of the drug from plasma. Domino Lab supports both interactive and batch experimentation with all popular IDEs and notebooks (Jupyter, RStudio, SAS, Zeppelin, etc.). The area under the first moment curve would respectively be. cl_f = NCA.cl(pain_nca)
Unlike experimentation in some other areas, LSOS experiments present a surprising challenge to statisticians — even though we operate in the realm of “big data”, the statistical uncertainty in our experiments can be substantial. We must therefore maintain statistical rigor in quantifying experimental uncertainty.
Despite a very large number of experimental units, the experiments conducted by LSOS cannot presume statistical significance of all effects they deem practically significant. The result is that experimenters can’t afford to be sloppy about quantifying uncertainty. In statistics, such segments are often called “blocks” or “strata”.
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